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Honeybee venom ‘kills some breast cancer cells’ according to scientists

Some good news!

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Scientists have found an exciting discovery that the venom from honeybees can destroy aggressive breast cancer cells, under lab conditions.

Breast cancer is the most common cancer that affects women globally, and while there are thousands of chemical compounds that can fight cancer cells in lab settings, few can be produced as actual treatments for humans. 

Similarly, the scientists involved in this experiment have cautioned that further testing is needed, however they have confirmed in lab settings the venom – a compound called melittin – has been used against two cancer types which are usually hard to treat, triple-negative and HER2-enriched. 

Published in a peer-reviewed journal, Nature Precision Oncology, the study took place by the Harry Perkins Institute of Medical Research in Western Australia.

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The testing used the venom from 312 honeybees and bumblebees from Perth Western Australia, Ireland and England to see the effect of the venom on sub-types of breast cancer, including triple-negative breast cancer, which has limited treatment options.

Previous research found that bee venom contains anti-cancer properties for other types of cancer such as melanoma. 

The PhD researcher who led the research, Ciara Duffy, explained that previously the effects on different sub-types of breast cancer and normal cells had not been compared. Duffy added that the venom was ‘extremely potent’. 

The researchers found that the melittin compound on its own was effective in ‘shutting down’ or disrupting cancer cell growth. One concentration of the venom killed the cancer cells within an hour with minimal harm to other cells.

Duffy said: “We found that melittin can completely destroy cancer cell membranes within 60 minutes.”

Other dosage levels were found to be more toxic. 

Melittin naturally occurs in honeybee venom, but could also be synthetically produced. 

Western Australia’s chief scientist described the research as ‘incredibly exciting’.

Prof Peter Klinken said: “Significantly, this study demonstrates how melittin interferes with signalling pathways within breast cancer cells to reduce cell replication.

“It provides another wonderful example of where compounds in nature can be used to treat human diseases.”

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Associate Prof Alex Swarbrick, from the Garvan Institute of Medical Research in Sydney, said regarding the research, ‘it’s very early days’. 

He told the BBC: “Many compounds can kill a breast cancer cell in a dish or in a mouse. But there’s a long way to go from those discoveries to something that can change clinical practice.”

Duffy further added that ‘bumblebee venom was unable to induce cell death even at very high concentrations’ and that the effects of Perth honeybee venom to other honeybee populations in Ireland and England, as well as to the venom of bumblebees, should be compared.

Future studies should assess the optimum method of delivery of melittin, as well as toxicities and maximum tolerated doses.

You can find out more here.

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Man arrested in connection with death of Gogglebox star George Gilbey

He has been arrested on suspicion of gross negligence manslaughter, police say

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@georgegilbey / Instagram

A man has been arrested in connection to the death of television personality George Gilbey who died after suffering a fall at work.

Essex Police said it was called to an incident at a road in Shoebury, near Southend-on-Sea, following a report that a man had fallen from a height while at work.

An air ambulance was in attendance but sadly, the 40-year-old died at the scene.

@georgegilbey / Instagram

A spokesperson for Essex Police said: “We received a report of an incident at Campfield Road in Shoebury at around 10am this morning (March 27), during which a man who was working at height had fallen and sustained an injury.

“The ambulance service including air ambulance were in attendance. Sadly, the man died at the scene. We will continue liaising with partners including the Health and Safety Executive (HSE). A cordon remains in place at the scene.”

Gilbey, a self-employed electricain, starred in eight series of Channel 4’s Gogglebox  alongside his mother Linda McGarry and stepfather Pete McGarry, who passed away at the age of 71 in 2021. Gilbey also Celebrity Big Brother on Channel 5 in 2014, finishing fourth.

Channel 4 Gogglebox shared a statement on its official X account, saying: “George was part of the Gogglebox family for eight series alongside his mum Linda and step-dad Pete.

“Our thoughts and deepest condolences are with Linda, and George’s family and friends at this very sad time.”

Tributes from friends and fans have been pouring in online, as one person said: “Rest in peace George, thanks for all the laughs you gave me over the years. Bet Pete’s waiting for you with a pint xxx.”

Another wrote: “Thinking of your family. I’m so sorry to your mum especially. so much grief to deal with in such a short time the world can be so cruel.”

Celebrities have also been sharing tributes online after hearing the tragic news.

EastEnders actress Daniella Westbrook shared a photo of Gilbey and his mum on Instagram, and wrote beside it: “Goodnight, my darling friend George. I’m absolutely gutted.”

In a post on X, former Geordie Shore star Ricci Guarnaccio, and Celebrity Big Brother co-star, wrote: “Breaks my (heart) but @georgegilbey you are well and truely going to be missed my friend. Always lit up the room, cared for others & the memories we made I’ll cherish for ever brother. From CBB to speaking to you last week, I’m going to hugely miss you ma boiii! Love you G.”

And, Simon Minty wrote on Instagram: “So sorry to hear this. I really enjoyed watching George. Condolences to Linda and family.” 

In the latest update, police said the arrested man was in his 40s and from the Witham area of Essex, and that further updates would be announced ‘proactively’. The force said he was arrested on ‘suspicion of gross negligence manslaughter’.

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Police issue urgent appeal to find missing man from Tameside

Have you seen David?

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Greater Manchester Police

Greater Manchester Police has issued an urgent appeal to help find a man who was last seen in Tameside in the early hours of yesterday.

David, 40, was last seen on Sands Walk, Hyde, at around 12am on Wednesday March 27th.

He is believed to still have his mobile phone on him and to be somewhere in the Greater Manchester area, police say.

David is described as a white male, around 6 ft 2 ins tall, of slim build and a bald head with red facial hair. He also has tattoos on his arms and legs.

He was last seen wearing jeans, a black t-shirt and a black hoodie.

Anyone who has seen David or who may have any information about his whereabouts is urged to contact GMP on 0161 856 9325.

 

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Gogglebox star George Gilbey dies after fall from height at age 40

RIP George

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@georgegilbey / Instagram

Television personality George Gilbey who starred on Gogglebox has died after suffering a fall at work.

Essex Police said it was called to an incident at a road in Shoebury, near Southend-on-Sea, following a report that a man had fallen from a height while at work.

An air ambulance was in attendance but sadly, the 40-year-old died at the scene.

@georgegilbey / Instagram

A spokesperson for Essex Police said: “We received a report of an incident at Campfield Road in Shoebury at around 10am this morning (March 27), during which a man who was working at height had fallen and sustained an injury.

“The ambulance service including air ambulance were in attendance. Sadly, the man died at the scene. We will continue liaising with partners including the Health and Safety Executive (HSE). A cordon remains in place at the scene.”

Gilbey starred in eight series of Channel 4’s Gogglebox  alongside his mother Linda McGarry and stepfather Pete McGarry, who passed away at the age of 71 in 2021. Gilbey also Celebrity Big Brother on Channel 5 in 2014, finishing fourth.

Channel 4 Gogglebox shared a statement on its official X account, saying: “George was part of the Gogglebox family for eight series alongside his mum Linda and step-dad Pete.

“Our thoughts and deepest condolences are with Linda, and George’s family and friends at this very sad time.”

Tributes from friends and fans have been pouring in online, as one person said: “Rest in peace George, thanks for all the laughs you gave me over the years. Bet Pete’s waiting for you with a pint xxx.”

Another wrote: “Thinking of your family. I’m so sorry to your mum especially. so much grief to deal with in such a short time the world can be so cruel.”

Celebrities have also been sharing tributes online after hearing the tragic news.

EastEnders actress Daniella Westbrook shared a photo of Gilbey and his mum on Instagram, and wrote beside it: “Goodnight, my darling friend George. I’m absolutely gutted.”

In a post on X, former Geordie Shore star Ricci Guarnaccio, and Celebrity Big Brother co-star, wrote: “Breaks my (heart) but @georgegilbey you are well and truely going to be missed my friend. Always lit up the room, cared for others & the memories we made I’ll cherish for ever brother. From CBB to speaking to you last week, I’m going to hugely miss you ma boiii! Love you G.”

And, Simon Minty wrote on Instagram: “So sorry to hear this. I really enjoyed watching George. Condolences to Linda and family.” 

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