News
Honeybee venom ‘kills some breast cancer cells’ according to scientists
Some good news!
Scientists have found an exciting discovery that the venom from honeybees can destroy aggressive breast cancer cells, under lab conditions.
Breast cancer is the most common cancer that affects women globally, and while there are thousands of chemical compounds that can fight cancer cells in lab settings, few can be produced as actual treatments for humans.
Similarly, the scientists involved in this experiment have cautioned that further testing is needed, however they have confirmed in lab settings the venom – a compound called melittin – has been used against two cancer types which are usually hard to treat, triple-negative and HER2-enriched.
Published in a peer-reviewed journal, Nature Precision Oncology, the study took place by the Harry Perkins Institute of Medical Research in Western Australia.
The testing used the venom from 312 honeybees and bumblebees from Perth Western Australia, Ireland and England to see the effect of the venom on sub-types of breast cancer, including triple-negative breast cancer, which has limited treatment options.
Previous research found that bee venom contains anti-cancer properties for other types of cancer such as melanoma.
The PhD researcher who led the research, Ciara Duffy, explained that previously the effects on different sub-types of breast cancer and normal cells had not been compared. Duffy added that the venom was ‘extremely potent’.
The researchers found that the melittin compound on its own was effective in ‘shutting down’ or disrupting cancer cell growth. One concentration of the venom killed the cancer cells within an hour with minimal harm to other cells.
Duffy said: “We found that melittin can completely destroy cancer cell membranes within 60 minutes.”
Other dosage levels were found to be more toxic.
Melittin naturally occurs in honeybee venom, but could also be synthetically produced.
Western Australia’s chief scientist described the research as ‘incredibly exciting’.
Prof Peter Klinken said: “Significantly, this study demonstrates how melittin interferes with signalling pathways within breast cancer cells to reduce cell replication.
“It provides another wonderful example of where compounds in nature can be used to treat human diseases.”
Associate Prof Alex Swarbrick, from the Garvan Institute of Medical Research in Sydney, said regarding the research, ‘it’s very early days’.
He told the BBC: “Many compounds can kill a breast cancer cell in a dish or in a mouse. But there’s a long way to go from those discoveries to something that can change clinical practice.”
Duffy further added that ‘bumblebee venom was unable to induce cell death even at very high concentrations’ and that the effects of Perth honeybee venom to other honeybee populations in Ireland and England, as well as to the venom of bumblebees, should be compared.
Future studies should assess the optimum method of delivery of melittin, as well as toxicities and maximum tolerated doses.
News
Oasis announce huge reunion tour as Liam and Noel Gallagher ‘make peace’
The news we’ve all been waiting for!
After years of will-they-won’t-they speculation, Oasis are officially BACK together for a reunion tour.
The Gallagher brothers have put aside their differences in the name of music, making thousands of fans extremely happy in the process.
The band teased the news on their socials over the weekend, posting a video on Sunday morning with today’s date (Tuesday, August 27th) and the time 8am.
And now shows have been announced for multiple dates in the UK and Ireland, with tickets going live this Saturday, August 31st.
The legendary Mancunian rockers will take to the stage next summer, with gigs in Cardiff, London, Edinburgh, Dublin and, of course, Manchester.
15 years after splitting, the band confirmed they would be back for 14 shows, saying: “The guns have fallen silent. The stars have aligned. The great wait is over. Come see. It will not be televised”.
The gigs will be Oasis’s ‘only shows in Europe next year’, with tickets on sale this Saturday at 8am in Ireland and 9am in the UK.
The Oasis 2025 tour dates in full:
July
4th – Cardiff, Principality Stadium
5th – Cardiff, Principality Stadium
11th – Manchester, Heaton Park
12th – Manchester, Heaton Park
19th – Manchester, Heaton Park
20th – Manchester, Heaton Park
25th – London, Wembley Stadium
26th – London, Wembley Stadium
August
2nd – London, Wembley Stadium
3rd – London, Wembley Stadium
8th – Edinburgh, Scottish Gas Murrayfield Stadium
9th – Edinburgh, Scottish Gas Murrayfield Stadium
16th – Dublin, Croke Park
17th – Dublin, Croke Park
You can grab your tickets HERE.
News
Stagecoach hiring over 100 new bus drivers for Bee Network with £31k salaries
Fancy a career change?
Stagecoach Manchester is hiring over 100 new bus drivers to work from its Oldham depot, following the second phase of the Bee Network launch in March.
You can apply for a range of roles, from positions with no experience required to fully qualified bus drivers.
Successful applicants will receive full training as part of the job, and trainees will get paid to train. Then after only 12 months’ service at Stagecoach, drivers can expect to earn up to £16 per hour, which equates to £31.6K per year, before overtime.
As well as that, drivers that already hold a PCV licence may be eligible to receive a £1,200 joining bonus.
Stagecoach
There’s also a host of other benefits available to all Stagecoach employees, like 28 days paid holiday, generous pension and free Stagecoach bus travel for successful applicants and a companion.
Rob Jones, Managing Director at Stagecoach Manchester said: “Expanding our offering in Oldham means we’ll be investing more in the economy and supporting our local community, as well as strengthening our workforce.
“Whether you’re looking for a career change or you’re a fully qualified, experienced bus driver, there’s a role for everyone here in Oldham.
“We’re looking for personable and dedicated drivers who are ready to help us build on the success of the Bee Network and connect the people of Oldham and Greater Manchester with the places and people that are important to them.”
Stagecoach
Phil Cornwall, bus driver at Stagecoach Manchester, said: “I’ve been a driver at Stagecoach for 25 years and I couldn’t recommend it more.
“From the perks to the people to the passengers, it really is a great place to work.”
To apply, head to the Stagecoach website HERE.
Two men have now been charged with murder, following the discovery of a human torso in Kersal Dale.
As well as that, more suspected human remains were also discovered this morning, Monday April 29th, in an alleyway close to the railway lines off Worsley Road, Eccles.
This follows earlier discoveries of human remains over the past three weeks, at Kersal Dale, Blackleach Reservoir and Colliery Wood, all in Salford.
Greater Manchester Police
Michal Jaroslaw Polchowski (25/04/1956) and Marcin Majerkiewicz (10/04/1982) both of Worsley Road, Eccles, have been charged with murder.
They are set to appear at Tameside Magistrates Court this afternoon.
While formal identification is still ongoing, the remains found at Kersal Dale are believed to be of a local man in his 60s. The remains found at the other three locations are still to be tested, but police are confident they belong to the same victim.
ACC Sarah Jackson said: “We have had large numbers of officers, staff and specialists working diligently on this investigation over the last three weeks. It has been very much a large, collective effort, with the victim and family at the heart of it from the outset.
“We have specially trained officers deployed to support the family as they come to terms with this tragic news. They are aware of this morning’s further discovery and will continue to be kept up to date with how we are progressing.
“Despite the charges brought today, our work is far from over.
“The scenes we already have established in Bury and Salford will remain in place for much of this week whilst our searches and enquiries continue. Local officers will continue to patrol the impacted areas to provide reassurance.
“We will continue following every line of enquiry to recover and reunite the victim with his family, bringing a dignified end to this terrible scenario.
“I’d like to thank the communities of Salford and beyond for their cooperation throughout this investigation. I know this incident has come as a shock, and the support we’ve had from those in the area is very much appreciated.”
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